SR 9011 – 10mg Capsules (90 Count)
$74.97
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SR 9011
- Chemical Name: 3-(((4-chlorobenzyl)(5-nitrothiophen-2-yl)methyl)amino)methyl)-N-pentylpyrrolidine-1-carboxamide
- Other Name(s): SR9011, SR-9011
- CAS: 1379686-29-9
- Powder Purity: >99% HPLC
- Solubility: DMSO, Ethanol, Propylene Glycol
- Molar Mass: 479.04 g/mol
- Chemical Formula: C23H31CIN4O3S
- Short term storage (weeks): 0-4 °C under dry condition
- Long Term Storage (months): -20 °C under dry condition
- Shelf Life: At least 4 years if properly stored
- Melting Point: 37 °C
- Appearance: Off-white to beige fine powder, hygroscopic, acrid odor, acrid metallic taste
- Biological half-life: 2-4 hours
- Research Amount: 10mgs
SR 9011 is a REV-ERB-α/β agonist. REV-ERB nuclear receptors have a critical role in feedback regulation of the circadian oscillator. Both Bmal1 and Clock are direct REV-ERB target genes and loss of REV-ERB-α alters circadian behavior.
In vitro: SR 9011 dose-dependently increased the REV-ERB-dependent repressor activity assessed in HEK293 cells. In addition, SR 9011 potently and efficaciously suppressed transcription in a transfection assay using full-length REV-ERB-a along with a luciferase reporter driven by the Bmal1 promoter.
SR 9011 also suppressed the expression of BMAL1 messenger RNA in HepG2 cells in a REV-ERB-a/b-dependent manner. Moreover, SR 9011 inhibited the activity of the SCN clock, with reversible inhibition of circadian oscillations.
WARNING: THIS COMPOUND IS FOR LABORATORY USE ONLY. ALL PRODUCTS ARE STRICTLY FOR RESEARCH PURPOSES ONLY AND ARE NOT FOR HUMAN CONSUMPTION.
| Weight | 4 oz |
|---|---|
| Dimensions | 4 × 4 × 4 in |
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